RGPV B.Pharmacy 3rd Semester CBCS Syllabus

PHARMACEUTICAL CHEMISTRY-III(ORGANIC CHEMISTRY –II ) (Theory)

General methods of preparation and reaction of compounds superscripted with (*) to be explained.

To emphasize on definition, types, classification, principles/mechanisms, applications, examples

and differences:

Benzene and its derivatives

Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture,

resonance in benzene, aromatic characters, Huckel’s rule.

Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedel crafts alkylationreactivity,

limitations, Friedel crafts acylation.

Substituents, effect of substituents on reactivity and orientation of mono substituted benzene

compounds towards electrophilic substitution reaction .

Structure and uses of DDT, Saccharin, BHC and Chloramine

Phenols*

Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol,

cresols, resorcinol, naphthols.

Aromatic Amines*

Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts

Fats and Oils

Fatty acids – reactions.

Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.

Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value,

Reichert Meissl (RM) value – significance and principle involved in their determination.

Polynuclear hydrocarbons

Synthesis, reactions

Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane,

Triphenylmethane and their derivatives

Cyclo alkanes*

Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s

modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and

cyclobutane only.

Recommended Books (Latest Editions)

1. Organic Chemistry by Morrison and Boyd

2. Organic Chemistry by I.L. Finar , Volume-I

3. Textbook of Organic Chemistry by B.S. Bahl & Arun Bahl.

4. Organic Chemistry by P.L.Soni

5. Practical Organic Chemistry by Mann and Saunders.

6. Vogel’s text book of Practical Organic Chemistry

7. Advanced Practical organic chemistry by N.K.Vishnoi.

8. Introduction to Organic Laboratory techniques by Pavia, Lampman and Kriz.

 PHARMACEUTICAL CHEMISTRY-III(ORGANIC CHEMISTRY –II ) (Practical)

1. Experiments involving laboratory techniques

 Recrystallization

 Steam distillation

2. Determination of following oil values (including standardization of reagents)

 Acid value

 Saponification value

 Iodine value

3. Preparation of compounds

 Benzanilide/Phenyl benzoate/Acetanilide from Aniline/ Phenol /Aniline by acylation

 reaction.

 2,4,6-Tribromo aniline/Para bromo acetanilide from Aniline/ Acetanilide by halogenation

 (Bromination) reaction.

 5-Nitro salicylic acid/Meta di nitro benzene from Salicylic acid / Nitro benzene by nitration

 reaction.

 Benzoic acid from Benzyl chloride by oxidation reaction.

 Benzoic acid/ Salicylic acid from alkyl benzoate/ alkyl salicylate by hydrolysis reaction.

 1-Phenyl azo-2-napthol from Aniline by diazotization and coupling reactions.

 Benzil from Benzoin by oxidation reaction.

 Dibenzal acetone from Benzaldehyde by Claison Schmidt reaction

 Cinnammic acid from Benzaldehyde by Perkin reaction

 p-Iodo benzoic acid from p-amino benzoic acid

 PHYSICAL PHARMACEUTICS-II (Theory)

Drug stability: 

Reaction kinetics: zero, pseudo-zero, first & second order, units of basic rate

constants, determination of reaction order. Physical and chemical factors influencing the

chemical degradation of pharmaceutical product: temperature, solvent, ionic strength, dielectric

constant, specific & general acid base catalysis, Simple numerical problems. Stabilization of

medicinal agents against common reactions like hydrolysis & oxidation. Accelerated stability

testing in dating of pharmaceutical dosage forms. Photolytic degradation and its prevention

Rheology: 

Newtonian systems, law of flow, kinematic viscosity, effect of temperature, nonNewtonian

systems, pseudoplastic, dilatants, plastic, thixotropy, thixotropy in formulation,

determination of viscosity, capillary, falling Sphere, rotational viscometers.

Deformation of solids: Plastic and elastic deformation, Heckel equation, Stress, Strain, Elastic

Modulus

Coarse dispersion: 

Suspension, interfacial properties of suspended particles, settling in

suspensions, formulation of suspensions, emulsions and theories of emulsification. Physical

stability of emulsions, preservation of emulsions, rheological properties of emulsions, phase

equilibria and emulsion formulation.

Surface and interfacial phenomenon: 

Liquid interface, surface & interfacial tensions, surface

free energy, measurement of surface & interfacial tensions, spreading coefficient, adsorption at

liquid interfaces, surface active agents, HLB Scale, solubilisation, detergency, adsorption at solid

interface.

Colloidal dispersions: 

Classification of dispersed systems & their general characteristics, size &

shapes of colloidal particles, classification of colloids & comparative account of their general

properties. Optical, kinetic & electrical properties. Effect of electrolytes, coacervation,

peptization & protective action.

Recommended Books: (Latest Editions)

1. Physical Pharmacy by Alfred Martin, Sixth edition

2. Experimental pharmaceutics by Eugene, Parott.

3. Tutorial pharmacy by Cooper and Gunn.

4. Stocklosam J. Pharmaceutical calculations, Lea & Febiger, Philadelphia.

5. Liberman H.A, Lachman C., Pharmaceutical Dosage forms, Tablets, Volume-1 to 3, Marcel

 Dekkar Inc.

6. Liberman H.A, Lachman C, Pharmaceutical dosage forms. Disperse systems, volume 1, 2, 3.

Marcel Dekkar Inc.

7. Physical Pharmaceutics by Ramasamy C, and Manavalan

 PHYSICAL PHARMACEUTICS- II (Practical)

 1. Determination of surface tension of given liquids by drop count and drop weight method

 2. Determination of HLB number of a surfactant by saponification method

 3. Determination of Freundlich and Langmuir constants using activated char coal

 4. Determination of critical micellar concentration of surfactants

 5. Determination of viscosity of liquid using Ostwald’s viscometer

 6. Determination sedimentation volume with effect of different suspending agent

 7. Determination sedimentation volume with effect of different concentration of single

 suspending agent

 8. Determination of viscosity of semisolid by using Brookfield viscometer

 9. Determination of reaction rate constant first order.

10. Determination of reaction rate constant second order

11. Accelerated stability studies

 HUMAN ANATOMY AND PHYSIOLOGY-II (Theory)

Body fluids and blood

Body fluids, composition and functions of blood, hemopoeisis, formation of hemoglobin, anemia,

mechanisms of coagulation, blood grouping, Rh factors, transfusion, its significance and disorders of blood.

Lymphatic system

Lymphatic organs and tissues, lymphatic vessels, lymph circulation and functions of lymphatic system

Cardiovascular system

Heart – anatomy of heart, blood circulation, blood vessels, structure and functions of artery, vein and

capillaries, elements of conduction system of heart and heart beat, its regulation by autonomic nervous  system, cardiac output, cardiac cycle. Regulation of blood pressure, pulse, electrocardiogram and disorders

of heart.

Digestive system

Anatomy of GI Tract with special reference to anatomy and functions of stomach, ( Acid production in the stomach, regulation of acid production through parasympathetic nervous system, pepsin role in protein digestion) small intestine and large intestine, anatomy and functions of salivary glands, pancreas and liver,movements of GIT, digestion and absorption of nutrients and disorders of GIT.

Respiratory system

Anatomy of respiratory system with special reference to anatomy of lungs, mechanism of respiration,

regulation of respiration, Lung volumes and capacities, transport of respiratory gases, artificial respiration,resuscitation methods.

Urinary system

Anatomy of urinary tract with special reference to anatomy of kidney and nephrons, functions of kidney and urinary tract, physiology of urine formation, micturition reflex and role of kidneys in acid base balance, role of RAS in kidney and disorders of kidney.

Reproductive system

Anatomy of male and female reproductive system, Functions of male and female reproductive system, sex hormones, physiology of menstruation, fertilization, spermatogenesis, oogenesis, pregnancy and parturition.

Introduction to genetics

Chromosomes, genes and DNA, protein synthesis, genetic pattern of inheritance

Recommended Books (Latest Editions)

1. Essentials of Medical Physiology by K. Sembulingam and P. Sembulingam. Jaypee brothers medical publishers, New Delhi.

2. Anatomy and Physiology in Health and Illness by Kathleen J.W. Wilson, Churchill Livingstone, Newyork

3. Physiological basis of Medical Practice-Best and Tailor. Williams & Wilkins Co,Riverview,MI USA

4. Text book of Medical Physiology- Arthur C,Guyton andJohn.E. Hall. Miamisburg, OH, U.S.A.

5. Principles of Anatomy and Physiology by Tortora Grabowski. Palmetto, GA, U.S.A.

6. Textbook of Human Histology by Inderbir Singh , Jaypee brothers medical publishers, New Delhi.

7. Textbook of Practical Physiology by C.L. Ghai , Jaypee brothers medical publishers, New Delhi.

8. Practical workbook of Human Physiology by K. Srinageswari and Rajeev Sharma, Jaypee brother’s medical publishers, New Delhi.

Reference Books:

1. Physiological basis of Medical Practice-Best and Tailor. Williams & Wilkins Co, Riverview, MI USA

2. Text book of Medical Physiology- Arthur C, Guyton and John. E. Hall. Miamisburg, OH, U.S.A.

3. Human Physiology (vol 1 and 2) by Dr. C.C. Chatterrje ,Academic Publishers Kolka

 HUMAN ANATOMY AND PHYSIOLOGY (Practical)

1. Introduction to hemocytometry.

2. Enumeration of white blood cell (WBC) count

3. Enumeration of total red blood corpuscles (RBC) count

4. Determination of bleeding time and clotting time

5. Determination of clotting time

6. Estimation of hemoglobin content

7. Determination of blood group.

8. Determination of erythrocyte sedimentation rate (ESR).

9. Determination of heart rate and pulse rate.

10. Recording of blood pressure.

11. Determination of tidal volume and vital capacity.

12. Study of digestive, respiratory, cardiovascular systems, urinary and reproductive systems with the help of models, charts and specimens.

13. Recording of basal mass index.

14. Study of family planning devices and pregnancy diagnosis test.

15. Demonstration of total blood count by cell analyzer.

16. Permanent slides of vital organs and gonads.

 PHARMACEUTICAL MICROBIOLOGY (Theory)

Introduction, history of microbiology, its branches, scope and its importance.

Introduction to Prokaryotes and Eukaryotes

Study of ultra-structure and morphological classification of bacteria, nutritional requirements,

raw materials used for culture media and physical parameters for growth, growth curve,

isolation and preservation methods for pure cultures, cultivation of anaerobes, quantitative

measurement of bacterial growth (total & viable count).

Study of different types of phase microscopy, dark field microscopy and electron microscopy.

Identification of bacteria using staining techniques (simple, Gram’s & Acid fast staining) and

biochemical tests (IMViC).

Study of principle, procedure, merits, demerits and applications of Physical, chemical and

mechanical method of sterilization.

Evaluation of the efficiency of sterilization methods.

Equipments employed in large scale sterilization.

Sterility indicators.

Study of morphology, classification, reproduction/replication and cultivation of Fungi and

Virus.

Classification and mode of action of disinfectants

Factors influencing disinfection, antiseptics and their evaluation.

Evaluation of bactericidal & Bacteriostatic.

Sterility testing of products (solids, liquids, ophthalmic and other sterile products) according

to IP, BP and USP.

Designing of aseptic area, laminar flow equipments; study of different sources of

contamination in an aseptic area and methods of prevention, clean area classification.

Principles and methods of different microbiological assay. Methods for standardization of

antibiotics, vitamins and amino acids.

Assessment of a new antibiotic and testing of antimicrobial activity of a new substance.

General aspects-environmental cleanliness.

Types of spoilage, factors affecting the microbial spoilage of pharmaceutical products,

sources and types of microbial contaminants, assessment of microbial contamination and

spoilage.

Preservation of pharmaceutical products using antimicrobial agents, evaluation of microbial

stability of formulations.

Growth of animal cells in culture, general procedure for cell culture, Primary, established and

transformed cell cultures.

Application of cell cultures in pharmaceutical industry and research.

Recommended Books (Latest edition)

1. W. B. Hugo and A.D. Russel: Pharmaceutical Microbiology, Blackwell Scientific

publications, Oxford London.

2. Prescott and Dunn., Industrial Microbiology, 4th edition, CBS Publishers & Distributors,

Delhi.

3. Pelczar, Chan Kreig, Microbiology, Tata McGraw Hill edn.

4. Malcolm Harris, Balliere Tindall and Cox: Pharmaceutical Microbiology.

5. Rose: Industrial Microbiology.

6. Probisher, Hinsdill et al: Fundamentals of Microbiology, 9th ed. Japan

7. Cooper and Gunn’s: Tutorial Pharmacy, CBS Publisher and Distribution.

8. Peppler: Microbial Technology.

9. I.P., B.P., U.S.P. - latest editions.

10. Ananthnarayan: Text Book of Microbiology, Orient-Longman, Chennai

11. Edward: Fundamentals of Microbiology.

12. N.K.Jain: Pharmaceutical Microbiology, Vallabh Prakashan, Delhi

13. Bergeys manual of systematic bacteriology, Williams and Wilkins- A Waverly company

 PHARMACEUTICAL MICROBIOLOGY (Practical)

1. Introduction and study of different equipments and processing, e.g., B.O.D. incubator, laminar flow, aseptic hood, autoclave, hot air sterilizer, deep freezer, refrigerator, microscopes used in experimental microbiology.

2. Sterilization of glassware, preparation and sterilization of media.

3. Sub culturing of bacteria and fungus. Nutrient stabs and slants preparations.

4. Staining methods- Simple, Grams staining and acid fast staining (Demonstration).

5. Staining methods- Simple, Grams staining and acid fast staining (Student Practical)

6. Isolation of pure culture of micro-organisms by multiple streak plate technique.

7. Microbiological assay of antibiotics by cup plate method.

8. Motility determination by Hanging drop method.

9. Sterility testing of pharmaceuticals.

10. Bacteriological analysis of water

11. Biochemical test (IMViC reactions)

12. Revision Practical Class

 BIOCHEMISTRY (Theory)

Carbohydrate metabolism

 Glycolysis – Pathway, energetics and significance

 Citric acid cycle- Pathway, energetics and significance

 HMP shunt and its significance; Glucose-6-Phosphate dehydrogenase (G6PD) deficiency

 Glycogen metabolism Pathways and glycogen storage diseases (GSD)

 Gluconeogenesis- Pathway and its significance

 Hormonal regulation of blood glucose level and Diabetes mellitus

Biological oxidation

 Electron transport chain (ETC) and its mechanism.

 Oxidative phosphorylation & its mechanism and substrate level phosphorylation

 Inhibitors ETC and oxidative phosphorylation/Uncouplers

Lipid metabolism

 β-Oxidation of saturated fatty acid (Palmitic acid)

 Formation and utilization of ketone bodies; ketoacidosis

 De novo synthesis of fatty acids (Palmitic acid)

 Biological significance of cholesterol and conversion of cholesterol into bile acids, steroid

hormone and vitamin D

 Disorders of lipid metabolism: Hypercholesterolemia, atherosclerosis, fatty liver and obesity.

Amino acid metabolism

 General reactions of amino acid metabolism: Transamination, deamination and decarboxylation,

urea cycle and its disorders

 Catabolism of phenylalanine and tyrosine and their metabolic disorders (Phenyketonuria,

Albinism, alkeptonuria, tyrosinemia)

 Synthesis and significance of biological substances; 5-HT, melatonin, dopamine, noradrenaline,

adrenaline

 Catabolism of heme; hyperbillirubinemia and jaundice

Nucleic acid metabolism and genetic information transfer

 Biosynthesis of purine and pyrimidine nucleotides

 Catabolism of purine nucleotides and hyperuricemia and gout disease

 Organization of mammalian genome

 Structure of DNA and RNA and their functions

 DNA replication (semi conservative model)

 Transcription or RNA synthesis

 Genetic code, Translation or Protein synthesis and inhibitors

Biomolecules

 Introduction, classification, chemical nature and biological role of carbohydrate, lipids, nucleic

acids, amino acids and proteins.

Bioenergetics

 Concept of free energy, undergone and exergonic reaction, Relationship between free energy,

enthalpy and entropy, Redox potential.

 Energy rich compounds; classification; biological significances of ATP and cyclic AMP

Enzymes

 Introduction, properties, nomenclature and IUB classification of enzymes

 Enzyme kinetics (Michaelis plot, Line Weaver Burke plot)

 Enzyme inhibitors with examples

 Regulation of enzymes: enzyme induction and repression, allosteric enzymes regulation

 Therapeutic and diagnostic applications of enzymes and isoenzymes

 Coenzymes –Structure and biochemical functions

Recommended Books (Latest Editions)

1. Principles of Biochemistry by Lehninger.

2. Harper’s Biochemistry by Robert K. Murry, Daryl K. Granner and Victor W. Rodwell.

3. Biochemistry by Stryer.

4. Biochemistry by D. Satyanarayan and U.Chakrapani.

5. Textbook of Biochemistry by Rama Rao.

6. Textbook of Biochemistry by Deb.

7. Outlines of Biochemistry by Conn and Stumpf

8. Practical Biochemistry by R.C. Gupta and S. Bhargavan.

9. Introduction of Practical Biochemistry by David T. Plummer. (3rd Edition)

10. Practical Biochemistry for Medical students by Rajagopal and Ramakrishna.

11. Practical Biochemistry by Harold Varley.

 BIOCHEMISTRY (Practical)

1. Qualitative analysis of carbohydrates (Glucose, Fructose, Lactose, Maltose, Sucrose and

starch)

2. Identification tests for Proteins (albumin and Casein)

3. Quantitative analysis of reducing sugars (DNSA method) and Proteins (Biuret method)

4. Qualitative analysis of urine for abnormal constituents

5. Determination of blood creatinine

6. Determination of blood sugar

7. Determination of serum total cholesterol

8. Preparation of buffer solution and measurement of pH

9. Study of enzymatic hydrolysis of starch

10. Determination of Salivary amylase activity

11. Study the effect of Temperature on Salivary amylase activity.

12. Study the effect of substrate concentration on salivary amylase activity.

 COMPUTER APPLICATIONS IN PHARMACY (Theory)

Number system: 

Binary number system, Decimal number system, Octal number system,

Hexadecimal number systems, conversion decimal to binary, binary to decimal, octal to binary etc,

binary addition, binary subtraction – One’s complement ,Two’s complement method, binary

multiplication, binary division.

Concept of Information Systems and Software:

Information gathering, requirement and feasibility

analysis, data flow diagrams, process specifications, input/output design, process life cycle, planning

and managing the project.

Web technologies: 

Introduction to HTML, XML, CSS and Programming languages, introduction to

web servers and Server Products.

Introduction to databases, MYSQL, MS ACCESS, Pharmacy Drug database.

Application of computers in Pharmacy – 

Drug information storage and retrieval, Pharmacokinetics,

Mathematical model in Drug design, Hospital and Clinical Pharmacy, Electronic Prescribing and

discharge (EP) systems, barcode medicine identification and automated dispensing of drugs, mobile

technology and adherence monitoring.

Diagnostic System, Lab-diagnostic System, Patient Monitoring System, Pharma Information System.

Bioinformatics: Introduction, Objective of Bioinformatics, Bioinformatics Databases, Concept of

Bioinformatics, Impact of Bioinformatics in Vaccine Discovery.

Computers as data analysis in Preclinical development: Chromatographic dada analysis

(CDS), Laboratory Information management System (LIMS) and Text Information Management

System (TIMS).

Recommended books (Latest edition):

1. Computer Application in Pharmacy – William E. Fassett –Lea and Febiger, 600 South

Washington Square, USA, (215) 922-1330.

2. Computer Application in Pharmaceutical Research and Development –Sean Ekins – WileyIntescience,

A John Willey and Sons, INC., Publication, USA

3. Bioinformatics (Concept, Skills and Applications) – S. C. Rastogi-CBS Publishers and

Distributiors 4596/1- A, 11 Darya Gani, New Delhi – 110 002(INDIA)

4. Microsoft office Access - 2003, Application Development Using VBA, SQL Server, DAP and

Infopath – Cary N. Prague – Wiley Dreamtech India (P) Ltd., 4435/7, Ansari Road, Daryagani,

New Delhi - 110002

 COMPUTER APPLICATIONS IN PHARMACY (Theory)

1. Design a questionnaire using a word processing package to gather information about a particular disease.

2. Create a HTML web page to show personal information.

3. Retrieve the information of a drug and its adverse effects using online tools

4. Creating mailing labels Using Label Wizard , generating label in MS WORD

5. Create a database in MS Access to store the patient information with the required fields Using access

6. Design a form in MS Access to view, add, delete and modify the patient record in the database

7. Generating report and printing the report from patient database

8. Creating invoice table using – MS Access

9. Drug information storage and retrieval using MS Access

10. Creating and working with queries in MS Access

11. Exporting Tables, Queries, Forms and Reports to web pages

12. Exporting Tables, Queries, Forms and Reports to XML pages

Continue Reading →

RGPV B.Pharmacy 3rd Semester Syllabus

               PHARMACEUTICS –III (PHARMACEUTICAL ENGINEERING -I)-PY 301 


Materials of Pharmaceutical Plant Construction- 
Factors affecting the material selection for pharmaceutical plants, Physical: Chemical;
Mechanical properties and use of the important materials of construction with special
reference to Ferrous metals, Copper, Aluminum, Nickel, Glass, Plastics and their alloys, Heat
and Corrosion resistant  alloys.

Corrosion and its Prevention –  
General considerations, Types of Corrosion, Methods of reducing Corrosion, Simple
mathematical problems.

 
Industrial Hazards and Safety measures-
Mechanical, Chemical, Electrical, Fire and Dust Hazards, Safety requirements, Legal
requirements, Industrial dermatitis.

Fluid Flow- 
Fluid statics, Manometers, Types of flow, Reynold’s Number and its significance, Concept of
boundary layers, Bernoulli’s theorem and its applications, Measurement of flow of – fluids,
Valves.

Material Handling Systems-
Liquid handling: Different types of pumps.
Solid handling : Conveyors

Heat Transfer-
Heat transfer mechanisms, Heat transfer by conduction, Fourier’s law, Natural and forced
convection, Surface and overall heat transfer coefficients, Heat transfer by radiation, Heaters
and heat exchangers.

Humidity, Air-
Conditioning and Refrigeration-
Basic concepts and definitions of various terms, Psychometric charts, Wet bulb theory,
Measurement of humidity, Application of humidity measurement, air-conditioning and
refrigeration in Pharmacy.

Automated Process Control Systems:
Process variables, Temperature, Pressure, Flow, Level and Vacuum and their measurements.
Elements of computer aided manufacturing (CAM).


LIST OF PRACTICALS

1. Determine the corrosion rate of different materials
2. Determine the corrosion rate of the metal in different environments
3. Calibrate a venturimeter and interpret the energy losses graphically.
4. Determine the rate of heat transfer using different materials.
5. Calculate the humidity at different places using dry bulb and wet bulb temperature method.
6. Determine the overall heat transfer coefficient of the given condenser
7. Determine the water vapour permeability across the given packaging material.
8. Determine the nature of flow of fluid and Reynolds Number by using Reynolds apparatus.
9. Determine the rate of flow of the given fluid by orifice meter.
10. Determine the rate of flow of the given fluid  by venturimeter
11. Determine the presser different by simple and differential manometers.  
12. Correlate falling factors and Reynolds Number using given pipe line assembly.
13. Determine the enlargement losses contraction losses and friction losses in a fluid flowing through a pipe.   14. Calculate the coefficient of discharge at orifice using orifice meter.

Books Recommended: 

1. J.F.Richardson and J.M. Coulron: Chemical Engineering 

2. Walter L. Badger and J.T. Banchero: Introduction to Chemical Engineering 

3. Perry: Handbook of Chemical Engineering 

4. Lauer & Heckmann: Chemical Engineering Techniques 

5. Peters: Elementary Chemical Engineering 

6. S.J. Carter: Tutorial Pharmacy 

7. N.D.Bhatt: Elementary Engineering Drawing. 

8. McCabe W.L. and Smith J.C. Unit Operation of Chemical Engineering Mc Graw Hill International Book Co., London. 

9. Cooper and Gunn’s Tutorial Pharmacy, CBS Publishers, New Delhi 

             


                  ANATOMY PHYSIOLOGY & HEALTH EDUCATION- II (PY-302)  


1. Digestive system –
Gross anatomy and histology of the gastrointestinal system, Functions of its different
parts
Oral cavity, Oesophagus, Stomach, Pancreas, liver, gall bladder, small intestine, large
intestine.
Various gastrointestinal secretions, its regulation and their role in the absorption and
digestion of food.
Overview of Disorders of digestive system, dental, caries’ disease,  periodontal cirrhosis,
hepatitis, gallstones, anorexia, peptic ulcers, appendicitis, gastrointestinal tumors.

2. Central Nervous System
Nevrohumoral transmission in the CNS
Organization of nervous systems. Histology and physiology of neurons.
Structure and function of brain and spinal cord, specialized function of cranial and spinal
nerves. Reflex action, Neurotransmitter in brain, Electroencephalogram.
Overview: CNS Disorder.  Parkinsorin,s cerebral palsy, poliomyelitis multiple sclerosis,
epilepsy, dyslexia, Trigeminal neuralgia, headache, Reyes syndrome, Alzheimer’s
Disease, Neuritis, Sciatica.  

3. The sensory, motor and integrative systems.

4. Autonomic Nervous system
Structure and physiology of Autonomic nervous system (Sympathetic and
parasympathetic).
Visceral autonomic reflexes, control by higher centers

5. Urinary System
Structure and functions of  the kidney and urinary tract  Physiology of urine formation,
acid-base balance.
Overview of Disorder of  urinary system, Gout, cystitis, nephrosis Renal failure,
glonerulonephritis , Urinary tract infection.  

6. Endocrime system
Endocrine glands, chemistry of hormones, mechanism of hormonal action, control of
hormonal secretion (Feed back mechanism) Anatomy and physiology of Pituitary,
thyroid, Parathyroid, Adrenals, Pancreas, ovaries, testes, thymus, Pineal, their hormones
and fuctions.
Overview of Disorders of endocrine system:
Pituitary dwarfism, giantism, acromegaly, diabetes, insipidus, cretinism, Myxedema,
exophthalmic goiter, al dosteronism, Addison’s disease, Cushing’s syndrome,
pheochromocytoma , Diabetes mellitus.

7. Reproductive system
Structure and function of made reproductive system testes, ductus epididymis vas
deferens, ejaculatory duct, urethra, seminal vesicles, prostate, gland, bulbourethral,
glands, penis, Hormones of male system and their regulation. Spermatogenesis, semen
Structure and function of female reproductive system, ovaries, uterine tubes, Vagina,
Vulva, mammary glands, Endocrine relations’ Menstrual and ovarian cycles Oogenesis,
coitus, Fertilization, pregnancy – its maintenance and parturition.
Overview of Disorders of Reproductive systems: - Sexually transmitted diseases
Gonorrhea, Syphilis, Genital herpes, Trichomoniasis, Prostatis impotence, in fertility,
Menstrual, abnormalities (Amenorrhea, dysmenorrheal) Ovarian cysts, endometriosis,
cervical cancer, prostate cancer, breast cancer.

8. Sense Organ
Basic anatomy, Physiology of eye (Vision), ear (hearing), taste buds, nose (smell) and
skin (superficial receptors).
 
List of Practicals:  

1.  To study human digestive system with help of  chart and models and study histology
of salivary glands, esophagus, stomach, Pancreas, liver, small intestine, large intentine.
2. To study human urinary system with help of chart and models study histology of
nephron, urinary bladder, Ureter
3. To study made and female reproductive system with help of chart and models and
study histology of testes, ductus, epididymis, ovary, uterus, mammary glands.
4. To study brain and spinal cord with help of chart and models and study histology of
cerebrum, cerebellum, spinal cord
5. To study structure and physiology of special senses
6. To study structure and physiology of Eye
7. To study structure and physiology of Ear
8. To study structure and physiology of Skin
9. To study structure and physiology of Taste buds
10. To study structure and physiology of Nose
11. To perform urine analysis for physiological (normal) constituent present in urine
sample
12. To study pathological (abnormal) constituent in the urine sample.
13. To perform quantitative test for presence of glucose in urine sample    

Books Recommended 

1. Gerard J. Tortora and Nicholas P. Anagnostakos ; Principles of Anatomy and physiology.Harper and Row publishers, New York. 

2. Sujit K. Chaudhuri: Concise Medical Physiology. 

3. C.C. Chatterjee: Human Physiology. 

4. Kathleen J.W., Wilson Ross and Wilson: Anatomy and Physiology in Health and Illness 

5. Arthur C. Guyton: Textbook of Medical Physiology. 

6. Cyril A. Keele, Erie Neil, Norman Joels and Samson Wrights: Applied Physiology 

7. Chatterjee, C.C, Human Physiology, Medical allied agency, Calcutta. 

8. Shalya, Subhas, Human Physiology CBS publisher Delhi. 

9. Ross and Wilson, Human anatomy and Physiology, Churchill Livingstone London. 

10. Chaurasia, B.D, Human anatomy, Regional and applied. , CBS publisher New Delhi  


             

          PHARMACEUTICAL CHEMISTRY IV (ORGANIC CHEMISTRY II) - PY-303 


1. Photochemistry and Pericyclic reaction
Theory-energy transfer-characteristics of photoreactions – typical photoreaction.
Electrocyclic reaction–sigmatropic rearrangement cycloaddition reactions. Neighboring
group effect, Catalysis by transition metal complexes.

2. Heterocyclic Chemistry
Nomenclature of Heterocycles
Nomenclature (Hantzsch-Widman system) for monocyclic (three, four, five, six and large
membered), fused and bridged heterocycles.

Aromatic and Non-aromatic Heterocycles
General chemical behaviour of aromatic heterocycles, classification (structural type),
Heteroaromatic reactivity and tautomerism in aromatic heterocycles, Strain–bond angle
and torsional strains and their consequences in small ring heterocycles
Synthesis, chemical reactivity and medicinal application of the following heterocycles
Three and four-membered heterocycles: aziridines and azetidines

Five membered hetero cycles: Furan, thiophen, pyrrole, pyrazole, oxazole, imidazole,
triazole.
Benzo-Fused Five-Membered Heterocycles: Benzimidazole, benzthiazole and benztriazole.
Six-Membered Heterocycles with One, Two or More Heteroatoms: Pyridine and
Pyrimidine.

Fused heterocycles: Quinoline, isoquinoline, acridine, coumarins.

 
3. Organic Compounds with functional group containing nitrogen
 Structure, nomenclature of nitro and cyano compounds.
Nitro compounds: Important methods of preparation, physical properties and chemical
reactions.
Cyanides and isocyanides: preparation, physical properties and chemical reactions.
4. Structure, Nomenclature and reactivity of Sulphur containing compounds

List of Practicals:
1. Synthesis and Characterization of – Benzthiazole.
2. Synthesis and Characterization of Quinoline.
3. Synthesis and Characterization of Benzimidazole.
4. Synthesis and Characterization of triazoles.
5. Synthesis and Characterization of pyrimidines.
6. Synthesis and Characterization of acridines.
7. Synthesis and Characterization of cuomarins.
8. Synthesis and Characterization of azipine.
9. Synthesis and Characterization of oxazole.
10. Synthesis and Characterization of picric acid.
11. Synthesis and Characterization of 3- nitro benzaldyhyde.
12. Synthesis and Characterization of 2 – mercapto oxadiazole.
13. Synthesis and Characterization of thiazolidinedione.
14. To perform the reduction of aromatic nitro group 2- amino group (Nitro benzene to
aniline, nitrobenzoic acid to amino benzoic acid, etc)  


                           
                             PHARMACEUTICAL MICROBIOLOGY - PY 304 


1. Introduction to the Science of Microbiology: Historical development, contribution of great
scientists and scope of microbiology.

 
2. Microbiology Taxonomy- Classification of Bacteria and Viruses

3. Identification of Microbes:
 Working of different types of microscopes, electron microscopy, stains and types of
staining techniques.
 Structure and Morphology of bacteria and viruses.
 Nutritional requirements, Cultivation and isolation of bacteria and viruses.

4. Microbial genetics and variation.

5. Control of microbes by physical and chemical methods
a. Disinfection: factors influencing disinfection, dynamics of disinfection.
b. Disinfectants and antiseptics, and their evaluation
c. Sterilization: Different methods, Validation of sterilization methods and
equipments.
6. Sterility testing of pharmaceutical products.

7. Infection and factors influencing infection, immunity, Primary and Secondary defensive mechanism of body, Microbial resistance, Interferon.

8. Microbial diseases:  Brief outline of communicable diseases. Their causative agents, Mode of transmission and prevention – Chicken pox, Measles, influenza, Diphtheria, Whooping, cough, Tulberculosis, Poliomyelitis, Hepatitis, Cholera, Typhoid, Food poisoning, Helminthiasis, Malaria, Filariasis, Rabies, Trachoma, Tetanus, Syphilis, Syphilis, Gonorrhoea and AIDS.
Microbial assay of antibiotics and vitamins.
Food spoilage and Preservation of food.
Sewage and Sewage disposal: Industrial Sewage, Sewage treatment methods, BOD, COD etc.

LIST OF PRACTICALS 

1. Study the motility of the given sample of microorganism by hanging drop technique.
2. Identify the given sample of organism by simple staining technique
3.  Identify the given sample of organism by Gram staining technique
4. Identify the given sample of organism by negative staining.
5. Identify the bacteria by performing IMViC test.
6. Prepare various types of culture media (Nutrient broth, nutrient agar, fluid thioglycolate
media etc)
7. Prepare subculture of the given sample of microorganism by aseptic transfer technique.
8. Evaluate the given sample of disinfectant by R.W. Coefficient test.
9. Determine the sterility of the given sample by filtration method.
10. Determine the sterility of the given sample by direct inoculation method.
11. Evaluate the given sample of an antibiotic microbiologically by filter paper disc method.
12. Evaluate the given sample of an antibiotic microbiologically by cup plate method.
13. Assay the given sample of vitamin microbiologically.
.


                                 PHARMACOGNOSY-II (Theory) -PY 305 

1. General methods of, isolations classification chemical properties and chemical tests and
systematic pharmacognostical studies of  
a) Glycosides, and drugs belongs to this class: Liquorice, Ginseng, Dioscorea,
Sarasaparilla, Senega, Digitalis, Squill, Rhubarb, Cascara, Aloe, Senna, Psorelea, Gentian,
Saffron, Chirata, Quassia, Thevetia, Mustard, Picrorrhiza
b) Volatile oils and drugs belongs to this class:  Dill, Fennel, Coriander, Caraway, Cassia
bark, Cinnamon bark, Clove, Nutmeg, Cardamom, Musk, Palmrosa, Gaultheria, Valerian, Black
Pepper, Lemon grass, Sandal wood Orange peel, Henna.

2. Enzymes, Biological sources, preparation, properties, identification tests and uses of Diastase,
Papain, Pepsin, Trypsin and Pancreatin.

3. Plant bitters and Sweetners.

4. Biological Source, identification characters chemical constituents and therapeutics uses of
traditional drugs like:  Kantkari, Satavari, Guduchi, Punarnava, Chitrak, Apamarga, Gokhru,
Shankhpushpi, Adusa, Brahmi, Methi, Garlic Nagarmotha, Neem, Shilajit Kapur kachari, Acorus

5. The holistic concept of drug administration in Ayurvedic and Traditional system of medicine.
Introduction to preparations like Asava, Arishta, Tailas, Churnas, Lepas, Lehyas and Bhasmas
and their evaluation schemes.  

LIST OF PRACTICALS: 

1. Morphological identification of  Senna pod, Squill Aloe, Senega
2. Morphological identification of Satavari, Guduchi, Apamarga Gokharu
3. Morphological identification of Nagarmotha, Neem, Garlic, Methi seed
4. Morphological identification of Nutmeg, Cardamom fruits and seeds.
5. Morphological and Microscopical identification of Senna leaf.
6. Morphological and Microscopical identification of Liquorice.
7. Morphological and Microscopical identification of Rhubarb.
8. Morphological and Microscopical identification of Dill & Fennel.
9. Morphological and Microscopical identification of Caraway & Coriander.
10. Morphological and Microscopical identification of Cinnamon bark & clove.
11. Identify the given mixture/sample of powder drug by morphological,
microscopical & chemical evaluation of senna cinnamon Rhubarb Coriander.
12. General studies of marketed formulations.

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